Pemetrexed is mildly active with good tolerability in treating patients with gastric cancer.

نویسندگان

  • Hai Lan
  • Cong-Yao Lin
  • Yan Li
چکیده

BACKGROUND This systemic analysis was conducted to evaluate the efficacy and safety of pemetrexed based chemotherapy in treating patients with metastatic gastric cancer (MGC) as a salvage chemotherapy. METHODS Clinical studies evaluating the efficacy and safety of pemetrexed based regimens on response and safety for patients with gastric cancer were identified by using a predefined search strategy. Pooled response rates (RRs) of treatment were calculated. RESULTS In pemetrexed based regimens, 4 clinical studies including 171 patients with advanced gastric cancer were considered eligible for inclusion. Systemic analysis suggested that, in all patients, pooled RR was 25.1% (43/171) in pemetrexed based regimens. Major adverse effects were neutropenia, anorexia, fatigue, and anemia. No treatment related death occurred in pemetrexed based treatment. CONCLUSION This systemic analysis suggests that pemetrexed based regimens are associated with mild activity with good tolerability in treating patients with MGC.

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عنوان ژورنال:
  • Asian Pacific journal of cancer prevention : APJCP

دوره 15 17  شماره 

صفحات  -

تاریخ انتشار 2014